The mutant achieved 3.1-fold higher ATP-generating activity and 1.7-fold higher GSH productivity compared with the control strain
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Tumor cells promote an angiogenic switch in endothelial cells by secreting pro-angiogenic factors such as VEGF, platelet-derived growth factor (PDGF), and angiopoietin 2 (Ang-2), inducing the destabilization of the endothelial cell barrier and promoting endothelial cell migration and proliferation (22)
Kits for caspase-3 and mitochondrial membrane potential assays were purchased from R&D System, MN, USA